Gold, P. & Freedman, S. O. Demonstration of tumor-specific antigens in human colonic cardinomata by immunological tolerance and absorption techniques. J. Exp. Med. 121, 439–462 (1965).
Wide, L., Roos, P. & Gemzell, C. Immunological determination of human pituitary luteinizing hormone (LH). Acta Endocrinol. 37, 445–449 (1961).
LaDue, J. S., Wróblewski, F. & Karmen, A. Serum glutamic oxaloacetic transaminase activity in human acute transmural myocardial infarction. Science 120, 497–499 (1954).
Raizada, A. et al. Brain type natriuretic peptide (BNP)—as marker of new millennium in diagnosis of congestive heart failure. Indian J. Clin. Biochem. 22, 4–9 (2007).
Montalescot, G., Guedeney, P. & Tijssen, J. A multi-biomarker score for a global approach of risk: time for a change?. J. Am. Coll. Cardiol. 80, 898–901 (2022).
Hye, A. et al. Proteome-based plasma biomarkers for Alzheimer’s disease. Brain 129, 3042–3050 (2006).
Ueno, I., Sakai, T., Yamaoka, M., Yoshida, R. & Tsugita, A. Analysis of blood plasma proteins in patients with Alzheimer’s disease by two-dimensional electrophoresis, sequence homology and immunodetection. Electrophoresis 21, 1832–1845 (2000).
Cao, M. C. et al. Serum biomarkers of neuroinflammation and blood–brain barrier leakage in amyotrophic lateral sclerosis. BMC Neurol. 22, 216–216 (2022).
de Ávila, B. E.-F. et al. Multiplexed determination of amino-terminal pro-B-type natriuretic peptide and C-reactive protein cardiac biomarkers in human serum at a disposable electrochemical magnetoimmunosensor. Electroanalysis 26, 254–261 (2014).
Sonawane, M. D., Nimse, S. B., Song, K. S. & Kim, T. Multiplex detection of cardiac biomarkers. Anal. Methods 9, 3773–3776 (2017).
Zhang, D. et al. Quantitative detection of multiplex cardiac biomarkers with encoded SERS nanotags on a single T line in lateral flow assay. Sens. Actuators B 277, 502–509 (2018).
An, B. et al. An antibody-free platform for multiplexed, sensitive quantification of protein biomarkers in complex biomatrices. J. Chromatogr. A 1676, 463261–463261 (2022).
Najjar, D. et al. A lab-on-a-chip for the concurrent electrochemical detection of SARS-CoV-2 RNA and anti-SARS-CoV-2 antibodies in saliva and plasma. Nat. Biomed. Eng. 6, 968–978 (2022).
Leandersson, P., Åkesson, A., Hedenfalk, I., Malander, S. & Borgfeldt, C. A multiplex biomarker assay improves the diagnostic performance of HE4 and CA125 in ovarian tumor patients. PLoS ONE 15, e0240418 (2020).
Ma, S. et al. Multiplexed serum biomarkers for the detection of lung cancer. eBioMedicine 11, 210–218 (2016).
Opstal-van Winden, A. et al. A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum. Int. J. Mol. Sci. 13, 13587–13604 (2012).
Pan, S. et al. Multiplex targeted proteomic assay for biomarker detection in plasma: a pancreatic cancer biomarker case study. J. Proteome Res. 11, 1937–1948 (2012).
Cook, D. B. et al. Multiplexing protein and gene level measurements on a single Luminex platform. Methods 158, 27–32 (2019).
Wilson, D. H. et al. The Simoa HD-1 analyzer: a novel fully automated digital immunoassay analyzer with single-molecule sensitivity and multiplexing. J. Lab. Autom. 21, 533–547 (2016).
Gold, L. et al. Aptamer-based multiplexed proteomic technology for biomarker discovery. PLoS ONE 5, e15004 (2010).
Rohloff, J. C. et al. Nucleic acid ligands with protein-like side chains: modified aptamers and their use as diagnostic and therapeutic agents. Mol. Ther. Nucleic Acids 3, e201 (2014).
O’Brien, J., Hayder, H., Zayed, Y. & Peng, C. Overview of microRNA biogenesis, mechanisms of actions, and circulation. Front. Endocrinol. 9, 402–402 (2018).
Romaine, S. P. R., Tomaszewski, M., Condorelli, G. & Samani, N. J. MicroRNAs in cardiovascular disease: an introduction for clinicians. Heart 101, 921–928 (2015).
Zhou, S. S. et al. miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges. Acta Pharmacol. Sin. 39, 1073–1084 (2018).
Schueller, F. et al. The role of miRNAs in the pathophysiology of liver diseases and toxicity. Int. J. Mol. Sci. 19, 261 (2018).
Connor, K. L. & Denby, L. MicroRNAs as non-invasive biomarkers of renal disease. Nephrol. Dial. Transplant. 36, 428–429 (2021).
Cao, D. D., Li, L. & Chan, W. Y. MicroRNAs: key regulators in the central nervous system and their implication in neurological diseases. Int. J. Mol. Sci. 17, 842 (2016).
Peng, Y. & Croce, C. M. The role of MicroRNAs in human cancer. Signal Transduct. Target. Ther. 1, 15004 (2016).
Qin, S. & Zhang, C. MicroRNAs in vascular disease. J. Cardiovasc. Pharmacol. 57, 8–12 (2011).
Mestdagh, P. et al. Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study. Nat. Methods 11, 809–815 (2014).
Lin, X., Ivanov, A. P. & Edel, J. B. Selective single molecule nanopore sensing of proteins using DNA aptamer-functionalised gold nanoparticles. Chem. Sci. 8, 3905–3912 (2017).
Ren, R. et al. Nanopore extended field-effect transistor for selective single-molecule biosensing. Nat. Commun. 8, 586 (2017).
Wanunu, M. et al. Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors. Nat. Nanotechnol. 5, 807–814 (2010).
Xue, L. et al. Solid-state nanopore sensors. Nat. Rev. Mater. 5, 931–951 (2020).
Sultan, M. & Kanavarioti, A. Nanopore device-based fingerprinting of RNA oligos and microRNAs enhanced with an osmium tag. Sci. Rep. 9, 14180 (2019).
Miles, B. N. et al. Single molecule sensing with solid-state nanopores: novel materials, methods, and applications. Chem. Soc. Rev. 42, 15–28 (2012).
Al Sulaiman, D., Cadinu, P., Ivanov, A. P., Edel, J. B. & Ladame, S. Chemically modified hydrogel-filled nanopores: a tunable platform for single-molecule sensing. Nano Lett. 18, 6084–6093 (2018).
Ren, R. et al. Selective sensing of proteins using aptamer functionalized nanopore extended field-effect transistors. Small Methods 4, 2000356 (2020).
Tan, S. et al. DNA-functionalized silicon nitride nanopores for sequence-specific recognition of DNA biosensor. Nanoscale Res. Lett. 10, 205 (2015).
Wei, R., Gatterdam, V., Wieneke, R., Tampé, R. & Rant, U. Stochastic sensing of proteins with receptor-modified solid-state nanopores. Nat. Nanotechnol. 7, 257–263 (2012).
Sze, J. Y. Y., Ivanov, A. P., Cass, A. E. G. & Edel, J. B. Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers. Nat. Commun. 8, 1552 (2017).
Cai, S., Sze, J. Y. Y., Ivanov, A. P. & Edel, J. B. Small molecule electro-optical binding assay using nanopores. Nat. Commun. 10, 1797 (2019).
Cai, S. et al. Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum. Nat. Commun. 12, 3515 (2021).
Liu, H. et al. Expression and purification of a novel mycobacterial porin MspA mutant in E. coli. J. Nanosci. Nanotechnol. 17, 9125–9129 (2017).
Deamer, D., Akeson, M. & Branton, D. Three decades of nanopore sequencing. Nat. Biotechnol. 34, 518–524 (2016).
One technology, one platform for all your biology. Oxford Nanopore Technologies https://nanoporetech.com/applications/techniques/short-fragment-mode (2023).
Kamanu, T. K. K., Radovanovic, A., Archer, J. A. C. & Bajic, V. B. Exploration of miRNA families for hypotheses generation. Sci. Rep. 3, 2940 (2013).
Craig, J. M. et al. Revealing dynamics of helicase translocation on single-stranded DNA using high-resolution nanopore tweezers. Proc. Natl Acad. Sci. USA 114, 11932–11937 (2017).
Chen, C. et al. Real-time quantification of microRNAs by stem–loop RT–PCR. Nucleic Acids Res. 33, e179 (2005).
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