Dewhirst, M. W. & Secomb, T. W. Transport of drugs from blood vessels to tumour tissue. Nat. Rev. Cancer 17, 738–750 (2017).
Blanco, E., Shen, H. & Ferrari, M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat. Biotechnol. 33, 941–951 (2015).
Wilhelm, S. et al. Analysis of nanoparticle delivery to tumours. Nat. Rev. Mater. 1, 16014 (2016).
Sindhwani, S. et al. The entry of nanoparticles into solid tumours. Nat. Mater. 19, 566–575 (2020).
Mitchell, M. J. et al. Engineering precision nanoparticles for drug delivery. Nat. Rev. Drug Discov. 20, 101–124 (2021).
Wettschureck, N., Strilic, B. & Offermanns, S. Passing the vascular barrier: endothelial signaling processes controlling extravasation. Physiol. Rev. 99, 1467–1525 (2019).
Glassman, P. M. et al. Targeting drug delivery in the vascular system: focus on endothelium. Adv. Drug Deliv. Rev. 157, 96–117 (2020).
Setyawati, M. I., Tay, C. Y., Docter, D., Stauber, R. H. & Leong, D. T. Understanding and exploiting nanoparticles’ intimacy with the blood vessel and blood. Chem. Soc. Rev. 44, 8174–8199 (2015).
Cahill, P. A. & Redmond, E. M. Vascular endothelium—gatekeeper of vessel health. Atherosclerosis 248, 97–109 (2016).
Zhou, Q. et al. Enzyme-activatable polymer–drug conjugate augments tumour penetration and treatment efficacy. Nat. Nanotechnol. 14, 799–809 (2019).
El-Kareh, A. W. & Secomb, T. W. A mathematical model for comparison of bolus injection, continuous infusion, and liposomal delivery of doxorubicin to tumor cells. Neoplasia 2, 325–338 (2000).
Hendriks, B. S. et al. Multiscale kinetic modeling of liposomal doxorubicin delivery quantifies the role of tumor and drug-specific parameters in local delivery to tumors. CPT Pharmacomet. Syst. Pharmacol. 1, e15 (2012).
Harashima, H., Iida, S., Urakami, Y., Tsuchihashi, M. & Kiwada, H. Optimization of antitumor effect of liposomally encapsulated doxorubicin based on simulations by pharmacokinetic/pharmacodynamic modeling. J. Control. Release 61, 93–106 (1999).
Jayadev, R. & Sherwood, D. R. Basement membranes. Curr. Biol. 27, R207–R211 (2017).
Nikolova, G., Strilic, B. & Lammert, E. The vascular niche and its basement membrane. Trends Cell Biol. 17, 19–25 (2007).
Reuten, R. et al. Basement membrane stiffness determines metastases formation. Nat. Mater. 20, 892–903 (2021).
Rowe, R. G. & Weiss, S. J. Breaching the basement membrane: who, when and how? Trends Cell Biol. 18, 560–574 (2008).
Chaudhuri, O. et al. Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium. Nat. Mater. 13, 970–978 (2014).
Zhang, X. L. et al. The endothelial basement membrane acts as a checkpoint for entry of pathogenic T cells into the brain. J. Exp. Med. 217, e20191339 (2020).
Du, B. J. et al. Glomerular barrier behaves as an atomically precise bandpass filter in a sub-nanometre regime. Nat. Nanotechnol. 12, 1096–1102 (2017).
Baluk, P., Morikawa, S., Haskell, A., Mancuso, M. & McDonald, D. M. Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am. J. Pathol. 163, 1801–1815 (2003).
Yuan, F. et al. Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Res. 54, 3352–3356 (1994).
Yokoi, K. et al. Capillary-wall collagen as a biophysical marker of nanotherapeutic permeability into the tumor microenvironment. Cancer Res. 74, 4239–4246 (2014).
Miao, L. & Huang, L. Exploring the tumor microenvironment with nanoparticles. Cancer Treat. Res. 166, 193–226 (2015).
Wang, S. W., Liu, J., Goh, C. C., Ng, L. G. R. & Liu, B. NIR-II-excited intravital two-photon microscopy distinguishes deep cerebral and tumor vasculatures with an ultrabright NIR-I AIE luminogen. Adv. Mater. 31, 1904447 (2019).
Iliff, J. J. et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci. Transl. Med. 4, 147ra111 (2012).
Yu, X. et al. Immune modulation of liver sinusoidal endothelial cells by melittin nanoparticles suppresses liver metastasis. Nat. Commun. 10, 574 (2019).
Mikelis, C. M. et al. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat. Commun. 6, 6725 (2015).
Bazzoni, G. & Dejana, E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol. Rev. 84, 869–901 (2004).
Mak, K. M. & Mei, R. Basement membrane type IV collagen and laminin: an overview of their biology and value as fibrosis biomarkers of liver disease. Anat. Rec. 300, 1371–1390 (2017).
Song, J. et al. Endothelial basement membrane laminin 511 contributes to endothelial junctional tightness and thereby inhibits leukocyte transmigration. Cell Rep. 18, 1256–1269 (2017).
Chang, J. L. & Chaudhuri, O. Beyond proteases: basement membrane mechanics and cancer invasion. J. Cell Biol. 218, 2456–2469 (2019).
Rayagiri, S. S. et al. Basal lamina remodeling at the skeletal muscle stem cell niche mediates stem cell self-renewal. Nat. Commun. 9, 1075 (2018).
Liotta, L. A. et al. Metastatic potential correlates with enzymatic degradation of basement-membrane collagen. Nature 284, 67–68 (1980).
Reymond, N., d’Agua, B. B. & Ridley, A. J. Crossing the endothelial barrier during metastasis. Nat. Rev. Cancer 13, 858–870 (2013).
Kelley, L. C., Lohmer, L. L., Hagedorn, E. J. & Sherwood, D. R. Traversing the basement membrane in vivo: a diversity of strategies. J. Cell Biol. 204, 291–302 (2014).
Zindel, J. et al. Primordial GATA6 macrophages function as extravascular platelets in sterile injury. Science 371, eabe0595 (2021).
Li, M. et al. Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy. Nat. Commun. 11, 1126 (2020).
Wang, J. et al. Visualizing the function and fate of neutrophils in sterile injury and repair. Science 358, 111–116 (2017).
Harris, T. J. C. & Tepass, U. Adherens junctions: from molecules to morphogenesis. Nat. Rev. Mol. Cell Biol. 11, 502–514 (2010).
Chauhan, V. P. et al. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat. Nanotechnol. 7, 383–388 (2012).
Orsenigo, F. et al. Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat. Commun. 3, 1208 (2012).
Wessel, F. et al. Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin. Nat. Immunol. 15, 223–230 (2014).
Paul, R. et al. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat. Med. 7, 222–227 (2001).
Miller, M. A. et al. Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts. Sci. Transl. Med. 9, eaal0225 (2017).
Matsumoto, Y. et al. Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery. Nat. Nanotechnol. 11, 533–538 (2016).
Igarashi, K. et al. Vascular bursts act as a versatile tumor vessel permeation route for blood-borne particles and cells. Small 17, 2103751 (2021).
Naumenko, V. A. et al. Extravasating neutrophils open vascular barrier and improve liposomes delivery to tumors. ACS Nano 13, 12599–12612 (2019).
Yeh, Y. T. et al. Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis. Proc. Natl Acad. Sci. USA 115, 133–138 (2018).
Pittet, M. J., Garris, C. S., Arlauckas, S. P. & Weissleder, R. Recording the wild lives of immune cells. Sci. Immunol. 3, eaaq0491 (2018).
Combes, F., Meyer, E. & Sanders, N. N. Immune cells as tumor drug delivery vehicles. J. Control. Release 327, 70–87 (2020).
Kurz, A. R. M. et al. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane. J. Clin. Invest. 126, 4125–4139 (2016).
Sreeramkumar, V. et al. Neutrophils scan for activated platelets to initiate inflammation. Science 346, 1234–1238 (2014).
Franco, A. T., Corken, A. & Ware, J. Platelets at the interface of thrombosis, inflammation, and cancer. Blood 126, 582–588 (2015).
Lv, Y. L. et al. Near-infrared light-triggered platelet arsenal for combined photothermal–immunotherapy against cancer. Sci. Adv. 7, eabd7614 (2021).
Miller, M. A., Askevold, B., Yang, K. S., Kohler, R. H. & Weissleder, R. Platinum compounds for high-resolution in vivo cancer imaging. ChemMedChem 9, 1131–1135 (2014).
- SEO Powered Content & PR Distribution. Get Amplified Today.
- PlatoData.Network Vertical Generative Ai. Empower Yourself. Access Here.
- PlatoAiStream. Web3 Intelligence. Knowledge Amplified. Access Here.
- PlatoESG. Automotive / EVs, Carbon, CleanTech, Energy, Environment, Solar, Waste Management. Access Here.
- PlatoHealth. Biotech and Clinical Trials Intelligence. Access Here.
- ChartPrime. Elevate your Trading Game with ChartPrime. Access Here.
- BlockOffsets. Modernizing Environmental Offset Ownership. Access Here.
- Source: https://www.nature.com/articles/s41565-023-01498-w
- :is
- ][p
- 06
- 07
- 08
- 1
- 10
- 11
- 12
- 13
- 14
- 15%
- 16
- 17
- 19
- 1994
- 1999
- 20
- 2000
- 2001
- 2006
- 2008
- 2012
- 2013
- 2014
- 2015
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 22
- 23
- 24
- 25
- 26
- 27
- 28
- 29
- 30
- 31
- 32
- 33
- 36
- 39
- 40
- 41
- 46
- 49
- 50
- 51
- 52
- 53
- 54
- 7
- 8
- 9
- a
- Act
- activated
- activity
- acts
- against
- AL
- amyloid
- an
- analysis
- and
- ARE
- Arsenal
- article
- AS
- At
- b
- barrier
- barriers
- based
- Beyond
- biology
- biomarkers
- blood
- blood vessels
- Brain
- Breaking
- by
- Cancer
- cell
- Cells
- cerebral
- clearance
- click
- combined
- comparison
- complete
- composition
- continuous
- contributes
- control
- controlled
- controlling
- deep
- delivery
- Design
- determines
- different
- Disease
- Diversity
- drug
- Drug Delivery
- Drugs
- during
- dynamically
- e
- E&T
- each
- effect
- efficacy
- encapsulated
- Engineering
- enhance
- entry
- enzymatic
- Ether (ETH)
- Exploring
- facilitate
- facilitates
- fate
- Ferrari
- filter
- flow
- Focus
- following
- For
- Forces
- formation
- from
- function
- Health
- high-resolution
- homeostasis
- How
- http
- HTTPS
- huang
- human
- i
- Imaging
- immune
- improve
- improves
- in
- Including
- induction
- inflammation
- infusion
- initiate
- Interface
- into
- invasion
- Invest
- ITS
- LINK
- Liver
- Lives
- local
- macrophages
- manner
- marker
- mathematical
- Matrix
- MCDONALD
- mechanics
- Meyer
- mice
- Microscopy
- model
- modeling
- MOL
- molecular
- muscle
- nanotechnology
- Nature
- NEO
- niche
- of
- on
- open
- optimization
- or
- organization
- overcoming
- overview
- parameters
- Passing
- pathway
- penetration
- platinum
- plato
- Plato Data Intelligence
- PlatoData
- potential
- precise
- Precision
- principles
- processes
- protection
- provides
- quantifies
- R
- Radiation
- recording
- regime
- Regulate
- Regulation
- repair
- Rock
- Role
- Route
- s
- sanders
- scan
- Scholar
- SCI
- solid
- Stealth
- Stem
- strategies
- system
- T
- T cells
- targeting
- The
- their
- therapy
- thereby
- three-dimensional
- Through
- tissue
- to
- trafficking
- transport
- treat
- treatment
- tumor
- tumors
- tumours
- type
- understanding
- value
- Vehicles
- versatile
- Vessel
- vessels
- via
- vivo
- W
- weiss
- when
- WHO
- Wild
- with
- X
- zephyrnet