Intracerebral fate of engineered nanoparticles – Nature Nanotechnology

Nanoparticle delivery to the brain has been an important area of technology development to improve diagnostic and treatment outcomes for brain diseases and injuries. So far, most research using nanoparticles for brain applications has focused on the delivery aspects — getting the nanoparticle to the site of interest and achieving the desired effect defines the scope of many studies. In general, nano-based delivery strategies have aimed at overcoming the highly selective blood–brain barrier in systemic delivery, and navigating the brain microenvironment to target and increase uptake within specific brain cells¹. This focus on delivery, and not on what happens after delivery is successful (or not), overlooks a critical component of using nanoparticles for brain applications: clearance. In a recent Nature Nanotechnology publication, Gao et al.² sought to fill this knowledge gap and answer the important question: what happens to nanoparticles after reaching the brain?

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• Source: https://www.nature.com/articles/s41565-023-01531-y