Design of erythrocyte-derived carriers for bioimaging applications

• Obireddy S.R.
• Lai W.F.

Multi-component hydrogel beads incorporated with reduced graphene oxide for pH-responsive and controlled co-delivery of multiple agents.

Pharmaceutics. 2021; 13: 313

• Lai W.F.
• et al.

Alginate-based complex fibers with the Janus morphology for controlled release of co-delivered drugs.

Asian J. Pharm. Sci. 2021; 16: 77-85

Non-aromatic clusteroluminogenic polymers: structural design and applications in bioactive agent delivery.

Mater. Today Chem. 2022; 23100712

• Zheng S.
• et al.

Noninvasive photoacoustic and fluorescent tracking of optical dye labeled T cellular activities of diseased sites at new depth.

J. Biophotonics. 2018; 11e201800073

• Chen R.H.
• et al.

Photoacoustic molecular imaging-escorted adipose photodynamic-browning synergy for fighting obesity with virus-like complexes.

Nat. Nanotechnol. 2021; 16: 455-465

• Wang C.
• et al.

Construction and evaluation of red blood cells-based drug delivery system for chemo-photothermal therapy.

Colloids Surf. B Biointerfaces. 2021; 204111789

• Malhotra S.
• et al.

Red blood cells-derived vesicles for delivery of lipophilic drug camptothecin.

ACS Appl. Mater. Inter. 2019; 11: 22141-22151

• Han X.
• et al.

Red blood cell-derived nanoerythrosome for antigen delivery with enhanced cancer immunotherapy.

Sci. Adv. 2019; 5: eaaw6870

• Della Pelle G.
• Kostevsek N.

Nucleic acid delivery with red-blood-cell-based carriers.

Int. J. Mol. Sci. 2021; 22: 5264

• Borgheti-Cardoso L.N.
• et al.

Extracellular vesicles derived from Plasmodium-infected and non-infected red blood cells as targeted drug delivery vehicles.

Int. J. Pharmaceut. 2020; 587119627

• Bidkar A.P.
• et al.

Transferrin-conjugated red blood cell membrane-coated poly(lactic-co-glycolic acid) nanoparticles for the delivery of doxorubicin and methylene blue.

ACS Appl. Nano Mater. 2020; 3: 3807-3819

• Yuan J.
• et al.

Cargo-laden erythrocyte ghosts target liver mediated by macrophages.

Transfus. Apher. Sci. 2021; 60102930

• Xia Q.
• et al.

Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application.

Acta Pharm. Sin. B. 2019; 9: 675-689

• Liu X.L.
• et al.

Haemoglobin-loaded metal organic framework-based nanoparticles camouflaged with a red blood cell membrane as potential oxygen delivery systems.

Biomater. Sci. 2020; 8: 5859-5873

• Soliman M.M.
• et al.

Polyethylene oxide-polyacrylic acid-folic acid (PEO-PAAc) nanogel as a Tc-99m targeting receptor for cancer diagnostic imaging.

J. Labelled Compd. Rad. 2021; 64: 534-547

• Mandal T.K.
• et al.

pH-Responsive biocompatible fluorescent core-shell nanogel for intracellular imaging and control drug release.

Part. Part. Syst. Charact. 2021; 38: 2100110

• Kimura A.
• et al.

Ultra-small size gelatin nanogel as a blood brain barrier impermeable contrast agent for magnetic resonance imaging.

Acta Biomater. 2021; 125: 290-299

• Lai W.F.
• Wong W.T.

Design of polymeric gene carriers for effective intracellular delivery.

Trends Biotechnol. 2018; 36: 713-728

• Lai W.F.
• Shum H.C.

A stimuli-responsive nanoparticulate system using poly(ethylenimine)-graft-polysorbate for controlled protein release.

Nanoscale. 2016; 8: 517-528

• Ma H.
• et al.

Mn-dox metal-organic nanoparticles for cancer therapy and magnetic resonance imaging.

Dyes Pigments. 2022; 199110080

• Lai W.F.
• et al.

Development of copper nanoclusters for in vitro and in vivo theranostic applications.

Adv. Mater. 2020; 32e1906872

• Magar K.T.
• et al.

Liposome-based delivery of biological drugs.

Chin. Chem. Lett. 2022; 33: 587-596

• Turchin I.
• et al.

Combined fluorescence and optoacoustic imaging for monitoring treatments against CT26 tumors with photoactivatable liposomes.

Cancers. 2022; 14: 197

• Medina T.P.
• et al.

Utilizing sphingomyelinase sensitizing liposomes in imaging intestinal inflammation in dextran sulfate sodium-induced murine colitis.

Biomedicines. 2022; 10: 413

• Lai W.F.
• et al.

Molecular design of layer-by-layer functionalized liposomes for oral drug delivery.

ACS Appl. Mater. Inter. 2020; 12: 43341-43351

• Khoshnejad M.
• et al.

Ferritin-based drug delivery systems: Hybrid nanocarriers for vascular immunotargeting.

J. Control. Release. 2018; 282: 13-24

• Dhanasooraj D.
• et al.

Vaccine delivery system for tuberculosis based on nano-sized hepatitis B virus core protein particles.

Int. J. Nanomedicine. 2013; 8: 835-843

• Zhu R.X.
• et al.

In vivo nano-biosensing element of red blood cell-mediated delivery.

Biosens. Bioelectron. 2021; 175112845

• Wan X.
• et al.

Red blood cell-derived nanovesicles for safe and efficient macrophage-targeted drug delivery in vivo.

Biomater. Sci. 2019; 7: 187-195

• Glassman P.M.
• et al.

Vascular drug delivery using carrier red blood cells: focus on RBC surface loading and pharmacokinetics.

Pharmaceutics. 2020; 12: 440

• Ferguson L.
• et al.

Targeted drug delivery to the pulmonary endothelium using liposomal nanocarriers and red blood cell super carriers.

Am. J. Resp. Crit. Care. 2021; 203: 1277752

• Bian H.
• et al.

Erythrocyte ghost based fusogenic glycoprotein vesicular stomatitis virus glycoprotein complexes as an efficient deoxyribonucleic acid delivery system.

J. Biomater. Tiss. Eng. 2022; 12: 1080-1086

• Hunault-Berger M.
• et al.

A phase 2 study of L-asparaginase encapsulated in erythrocytes in elderly patients with Philadelphia chromosome negative acute lymphoblastic leukemia: the GRASPALL/GRAALL-SA2-2008 study.

Am. J. Hematol. 2015; 90: 811-818

• Bax B.E.
• et al.

In vitro and in vivo studies with human carrier erythrocytes loaded with polyethylene glycol-conjugated and native adenosine deaminase.

Brit. J. Haematol. 2000; 109: 549-554

• Chessa L.
• et al.

Intra-erythrocyte infusion of dexamethasone reduces neurological symptoms in ataxia teleangiectasia patients: results of a phase 2 trial.

Orphanet. J. Rare Dis. 2014; 9: 5

• Bax B.E.
• et al.

Erythrocyte encapsulated thymidine phosphorylase for the treatment of patients with mitochondrial neurogastrointestinal encephalomyopathy: study protocol for a multi-centre, multiple dose, open label trial.

J. Clin. Med. 2019; 8: 1096

• Hammel P.
• et al.

Erythrocyte-encapsulated asparaginase (eryaspase) combined with chemotherapy in second-line treatment of advanced pancreatic cancer: an open-label, randomized Phase IIb trial.

Eur. J. Cancer. 2020; 124: 91-101

• Nguyen T.D.T.
• et al.

Erythrocyte membrane concealed paramagnetic polymeric nanoparticle for contrast-enhanced magnetic resonance imaging.

Nanoscale. 2020; 12: 4137-4149

• Yang Q.
• et al.

Erythrocyte membrane-camouflaged IR780 and DTX coloading polymeric nanoparticles for imaging-guided cancer photo-chemo combination therapy.

Mol. Pharm. 2019; 16: 3208-3220

• Xiao F.
• et al.

An erythrocyte membrane coated mimetic nano-platform for chemo-phototherapy and multimodal imaging.

RSC Adv. 2019; 9: 27911-27926

• Choi J.W.
• et al.

In vivo positron emission tomographic blood pool imaging in an immunodeficient mouse model using 18F-fluorodeoxyglucose labeled human erythrocytes.

PLoS One. 2019; 14e0211012

• Li Y.C.
• et al.

Clinical progress and advanced research of red blood cells based drug delivery system.

Biomaterials. 2021; 279121202

• Antonelli A.
• et al.

Development of long circulating magnetic particle imaging tracers: use of novel magnetic nanoparticles and entrapment into human erythrocytes.

Nanomedicine. 2020; 15: 739-753

• Sylvestre M.
• et al.

Progress on modulating tumor-associated macrophages with biomaterials.

Adv. Mater. 2020; 32e1902007

Heads or tails — what determines the orientation of proteins in the membrane.

FEBS Lett. 1995; 369: 76-79

• Gao W.W.
• et al.

Surface functionalization of gold nanoparticles with red blood cell membranes.

Adv. Mater. 2013; 25: 3549-3553

• Liang X.L.
• et al.

Prussian blue nanoparticles operate as a contrast agent for enhanced photoacoustic imaging.

Chem. Commun. 2013; 49: 11029-11031

• Mamontova E.
• et al.

Fashioning prussian blue nanoparticles by adsorption of luminophores: synthesis, properties, and in vitro imaging.

Inorg. Chem. 2020; 59: 4567-4575

• Cano-Mejia J.
• et al.

CpG-coated prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma.

Transl. Oncol. 2020; 13100823

• Busquets M.A.
• Estelrich J.

Prussian blue nanoparticles: synthesis, surface modification, and biomedical applications.

Drug Discov. Today. 2020; 25: 1431-1443

• Su J.
• et al.

Enhanced blood suspensibility and laser-activated tumor-specific drug release of theranostic mesoporous silica nanoparticles by functionalizing with erythrocyte membranes.

Theranostics. 2017; 7: 523-537

• Chen M.
• et al.

Erythrocyte-derived vesicles for circulating tumor cell capture and specific tumor imaging.

Nanoscale. 2019; 11: 12388-12396

• Rao L.
• et al.

Microfluidic electroporation-facilitated synthesis of erythrocyte membrane-coated magnetic nanoparticles for enhanced imaging-guided cancer therapy.

ACS Nano. 2017; 11: 3496-3505

• Wen Q.
• et al.

Erythrocyte membrane-camouflaged gefitinib/albumin nanoparticles for tumor imaging and targeted therapy against lung cancer.

Int. J. Biol. Macromol. 2021; 193: 228-237

• Burns J.M.
• et al.

Erythrocyte-derived theranostic nanoplatforms for near infrared fluorescence imaging and photodestruction of tumors.

ACS Appl. Mater. Interfaces. 2018; 10: 27621-27630

• Ren X.
• et al.

Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy.

Biomaterials. 2016; 92: 13-24

• Liu Y.G.
• et al.

Non-invasive photoacoustic imaging of in vivo mice with erythrocyte derived optical nanoparticles to detect CAD/MI.

Sci. Rep. 2020; 10: 5983

• Wang Z.G.
• et al.

Technological value of SPECT/CT fusion imaging for the diagnosis of lower gastrointestinal bleeding.

Genet. Mol. Res. 2015; 14: 14947-14955

• Wang S.W.
• et al.

In vivo imaging of rat vascularity with FDG-labeled erythrocytes.

Pharmaceuticals. 2022; 15: 292

• Burns J.M.
• et al.

Near infrared fluorescence imaging of intraperitoneal ovarian tumors in mice using erythrocyte-derived optical nanoparticles and spatially-modulated illumination.

Cancers. 2021; 13: 2544

• He G.
• et al.

In vivo imaging of a single erythrocyte with high-resolution photoacoustic microscopy.

Front. Optoelectron. 2015; 8: 122-127

• Gu B.Y.
• et al.

Noninvasive in vivo characterization of erythrocyte motion in human retinal capillaries using high-speed adaptive optics near-confocal imaging.

Biomed. Opt. Express. 2018; 9: 3653-3677

• Pottenburgh J.
• et al.

Use of FITC and CFSE labeled erythrocytes for in vivo retinal imaging in non-human primates.

Invest. Ophthalmol. Vis. Sci. 2020; 61: 897

• Wang Y.
• et al.

¹⁸F-positron-emitting/fluorescent labeled erythrocytes allow imaging of internal hemorrhage in a murine intracranial hemorrhage model.

J. Cerebr. Blood F Met. 2017; 37: 776-786

• Vankayala R.
• et al.

Erythrocyte-derived nanoparticles as a theranostic agent for near-infrared fluorescence imaging and thrombolysis of blood clots.

Macromol. Biosci. 2018; 18e1700379

• Zhang X.B.
• et al.

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy.

Bioact. Mater. 2021; 6: 2291-2302

• Yao Q.
• et al.

Aging erythrocyte membranes as biomimetic nanometer carriers of liver-targeting chromium poisoning treatment.

Drug Deliv. 2021; 28: 1455-1465

Flower, R.W. Methods for production and use of substance-loaded erythrocytes for observation and treatment of microvascular hemodynamics, ES2671710T3

Flower, R.W. Methods for production and use of substance-loaded erythrocytes (S-IEs) for observation and treatment of microvascular hemodynamics, US10041042B2

Flower, R.W. Methods for production and use of substance-loaded erythrocytes for observation and treatment of microvascular hemodynamics, EP3372250B1

Flower, R.W. Methods for production and use of substance-loaded erythrocytes for observation and treatment of microvascular hemodynamics, EP2285421B1

Coller, B.S. Method for preparing targeted carrier erythrocytes, US5328840A

Srivastava, S.C. et al. Method and kit for the selective labeling of red blood cells in whole blood with TC-99M, US4755375A

Kato, M. and Hazue, M. Composition for labeling of red blood cells with radioactive technetium, US4313928A

Schneider, D.R. and Bis, K.G. Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same, US5045304A

Chao, F. Platelet membrane microparticles, US5332578A

Fischer, T.H. et al. Delivery of micro- and nanoparticles with blood platelets, US8512697B2

Dacorta, J.A. et al. Spray-dried blood products and methods of making same, ES2684130T3

Dacorta, J.A. et al. Spray-dried blood products and methods of making same, CA2757961C

Dacorta, J.A. et al. Spray-dried blood products and methods of making same, AU2010234607B2

Dacorta, J.A. et al. Spray-dried blood products and methods of making same, EP2416790B1

Dacorta, J.A. et al. Spray-dried blood products and methods of making same, US9867782B2

• Xu Q.
• et al.

Multi-task joint learning model for segmenting and classifying tongue images using a deep neural network.

IEEE J. Biomed. Health Inform. 2020; 24: 2481-2489

• Zhang Z.
• et al.

Endoscope image mosaic based on pyramid ORB.

Biomed. Signal. Process. Control. 2022; 71103261

• Liu S.
• et al.

2D/3D multimode medical image registration based on normalized cross-correlation.

Appl. Sci. 2022; 12: 2828

• Liu Y.
• et al.

Improved feature point pair purification algorithm based on sift during endoscope image stitching.

Front. Neurorobot. 2022; 16840594

• Zhang T.
• et al.

Transcranial focused ultrasound stimulation of periaqueductal gray for analgesia.

IEEE Trans. Biomed. Eng. 2022; ()

• Zhang T.
• et al.

Piezoelectric ultrasound energy-harvesting device for deep brain stimulation and analgesia applications.

Sci. Adv. 2022; 8: eabk0159

• Tang W.
• et al.

Tumor origin detection with tissue-specific miRNA and DNA methylation markers.

Bioinformatics. 2018; 34: 398-406

• Pierige F.
• et al.

Cell-based drug delivery.

Adv. Drug Deliv. Rev. 2008; 60: 286-295

• Gutierrez Millan C.
• et al.

Factors associated with the performance of carrier erythrocytes obtained by hypotonic dialysis.

Blood Cells Mol. Dis. 2004; 33: 132-140

• Hamidi M.
• et al.

Preparation and in vitro evaluation of carrier erythrocytes for RES-targeted delivery of interferon-α 2b.

Int. J. Pharm. 2007; 341: 125-133

• Seth M.
• et al.

Dilution technique to determine the hydrodynamic volume fraction of a vesicle suspension.

Langmuir. 2010; 26: 15169-15176

• Magnani M.
• et al.

Erythrocyte-mediated delivery of drugs, peptides and modified oligonucleotides.

Gene Ther. 2002; 9: 749-751

• Lynch A.L.
• et al.

pH-responsive polymers for trehalose loading and desiccation protection of human red blood cells.

Biomaterials. 2011; 32: 4443-4449

• Liu X.
• et al.

Robust three-dimensional nanotube-in-micropillar array electrodes to facilitate size independent electroporation in blood cell therapy.

Lab Chip. 2021; 21: 4196-4207

• Nicolau C.
• Gersonde K.

Incorporation of inositol hexaphosphate into intact red blood cells. I. Fusion of effector-containing lipid vesicles with erythrocytes.

Naturwissenschaften. 1979; 66: 563-566

• Kwon Y.M.
• et al.

L-Asparaginase encapsulated intact erythrocytes for treatment of acute lymphoblastic leukemia (ALL).

J. Control. Release. 2009; 139: 182-189